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Related Experiment Videos

Taste function in patients with oral burning.

B K Formaker1, M E Frank

  • 1Division of Neurosciences, Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA. brad@neuron.uchc.edu

Chemical Senses
|October 4, 2000
PubMed
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Burning mouth syndrome (BMS) involves oral pain and taste changes, particularly in post-menopausal women. Research suggests pain pathways may alter taste perception, affecting salt and sweet intensity and quality identification.

Area of Science:

  • Neuroscience
  • Oral Medicine
  • Sensory Science

Background:

  • Burning mouth syndrome (BMS) is an oral pain disorder often affecting post-menopausal women.
  • BMS is frequently associated with taste disturbances, suggesting a link between pain (nociception) and taste (gustation).

Purpose of the Study:

  • To investigate taste function in patients with unexplained oral burning.
  • To explore the relationship between pain pathways and gustatory perception in BMS.

Main Methods:

  • Seventy-three patients reporting unexplained oral burning were assessed for taste function.
  • Intensity ratings and quality identifications of sweet, salty, sour, and bitter stimuli were measured.
  • Taste function in 57 women with BMS was compared to age- and sex-matched controls.

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Main Results:

  • BMS women reported lower intensity ratings for salt (NaCl) and sweet (sucrose) compared to controls, especially at higher concentrations (>0.10 M).
  • No intensity differences were observed for sour (citric acid) or bitter (quinine-HCl) stimuli.
  • BMS women misidentified taste qualities more frequently (19%) than controls (8%), particularly for salt and sour stimuli.

Conclusions:

  • Findings support the hypothesis that pain pathway activation in BMS can impact neural and behavioral aspects of taste function.
  • Altered taste perception, specifically for salt and sweet, may be a characteristic feature of BMS in women.
  • The study highlights a potential interaction between oral pain and gustatory processing.