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Updated: Jul 26, 2026

A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model
Published on: October 31, 2012
A new approach to prenatal treatment of extralobar pulmonary sequestration
1Department of Obstetrics and Gynecology, Ospedale V. Buzzi, University of Milano, Via Castelvetro 32, 20154 Milano, Italy. nicolini@mailserver.unimi.it
Abstract:
Fetal hydrothorax and hydrops is a frequent complication of extralobar pulmonary sequestration which is associated with a high perinatal mortality and severe respiratory insufficiency in the newborn. In a 27-week-old fetus with this condition, injection of 1 ml of pure alcohol and pleuro-amniotic shunting achieved resolution of hydrops. The pregnancy progressed to term and a healthy neonate was delivered who did not require postnatal surgery.
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