Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transferrin polymorphism influences iron status in blacks.

I Kasvosve1, J R Delanghe, Z A Gomo

  • 1Departments of Medicine and Chemical Pathology, Medical School, University of Zimbabwe, Harare, Zimbabwe.

Clinical Chemistry
|October 6, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the implementation of a multi-level mHealth study to improve hydroxyurea utilization in sickle cell disease.

Frontiers in health services·2023
Same author

Vitamin D and Vitamin D binding protein: the inseparable duo in COVID-19.

Journal of endocrinological investigation·2021
Same author

Corrigendum to "Protective effect of HLA-DQB1 alleles against alloimmunization in patients with sickle cell disease" [Hum. Immunol. (2016) 35-40].

Human immunology·2020
Same author

The potential influence of human Y-chromosome haplogroup on COVID-19 prevalence and mortality.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Diversity of Rotavirus Strains Circulating in Botswana before and after introduction of the Monovalent Rotavirus Vaccine.

Vaccine·2019
Same author

Variability of serum concentrations of cystatin C and urinary retinol-binding protein, neutrophil gelatinase-associated lipocalin, immunoglobulin G, and C-reactive protein in dogs.

Journal of veterinary internal medicine·2018

Transferrin (TF) phenotype differences impact iron status in Black populations. TF CD heterozygotes show reduced iron binding compared to TF CC homozygotes, affecting iron levels.

Area of Science:

  • Human Genetics
  • Biochemistry
  • Hematology

Background:

  • Genetic variations in human transferrin (TF) are known, but their functional implications remain unclear.
  • Investigating iron status across different TF phenotypes in Zimbabwean populations, including those at risk for African iron overload.

Purpose of the Study:

  • To determine functional differences in iron metabolism associated with various transferrin (TF) phenotypes.
  • To assess the impact of TF variants on iron status markers in healthy and iron-overload-risk populations.

Main Methods:

  • Phenotyping of transferrin (TF) using starch gel electrophoresis.
  • Measurement of serum iron, total iron-binding capacity (TIBC), ferritin, and soluble TF receptors.
  • Equilibrium dialysis to quantify iron binding capacity of TF variants.

Related Experiment Videos

Main Results:

  • A high TF D allele frequency was observed in the Zimbabwean population.
  • TF CD heterozygotes, particularly males, exhibited lower serum iron, TIBC, and TF saturation compared to TF CC homozygotes.
  • TF CD individuals demonstrated significantly reduced iron binding capacity.

Conclusions:

  • The study confirms functional differences between transferrin (TF) phenotypes in Black individuals.
  • These findings highlight the clinical relevance of TF genotype in iron metabolism and overload conditions.