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Related Experiment Videos

Ovarian fibrothecoma with massive edema.

M Sakaki1, M Hirokawa, H Horiguchi

  • 1Department of Pathology, University of Tokushima School of Medicine, Japan.

The Journal of Medical Investigation : JMI
|October 6, 2000
PubMed
Summary

This case report details a rare ovarian fibrothecoma with massive edema in a 59-year-old woman. Histological examination revealed a tumor with significant edematous changes, crucial for diagnosis.

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Area of Science:

  • Gynecologic pathology
  • Reproductive endocrinology
  • Oncology

Background:

  • Ovarian tumors can present with diverse histological features and clinical manifestations.
  • Massive edema is an uncommon finding in ovarian neoplasms, posing diagnostic challenges.

Observation:

  • A 59-year-old woman presented with a large left ovarian mass (11 x 10 x 7 cm).
  • MRI revealed a solid, unhomogeneous mass with high T2-weighted signal intensity.
  • Microscopically, the tumor comprised a cellular area and a hypocellular, edematous area (over 75% of the tumor).

Findings:

  • The cellular areas showed spindle-shaped cells with intracytoplasmic lipid and dense collagenous stroma.
  • The edematous areas contained scattered spindle or stellate cells with minimal stromal mucin.

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  • Histological features were consistent with ovarian fibrothecoma with massive edema.

    • Implications:

    • Distinguishing this rare entity from massive ovarian edema and sclerosing stromal tumor is critical.
    • Immunohistochemistry may not be definitive; careful histological assessment and patient age are key diagnostic factors.
    • This case highlights the importance of recognizing rare presentations of common ovarian tumors.