[Current aspects of differentiated therapy of infectious endocarditis]

150 patients (90 males and 60 females, mean age 41.9 +/- 3.3 years) with infectious endocarditis (IE) were treated. 26.7 and 71.3% of the patients had primary and secondary IE, respectively. Clinical and laboratory manifestations of the variants indicate that each variant is associated with a certain clinicolaboratory syndrome: acute IE is associated with toxicoseptic syndrome, subacute--with immune unbalance, and thromboembolic complications, chronic--with immunocomplex visceral lesions. Different variants of the course predetermine different therapy. It is recommended to combined active antibacterial therapy with UV radiation of autoblood and hemosorption, hyperbaric oxygenation. Immunocorrective and efferent therapy hold promise in IE treatment. Glucocorticosteroids are effective in immunocomplex disorders.