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Dose-response and onset/offset characteristics of rapacuronium.

A F Kopman1, M M Klewicka, K Ghori

  • 1Department of Anesthesiology, St. Vincent's Hospital and Medical Center of New York, New York City, New York, USA. AKopman@interport.net

Anesthesiology
|October 6, 2000
PubMed
Summary
This summary is machine-generated.

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This study determined the dose-response of rapacuronium, finding its effective dose (ED95) lower than previously estimated. Rapacuronium offers an onset similar to succinylcholine but a slower recovery than succinylcholine.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Clinical Pharmacology

Background:

  • Dose-response relationship of rapacuronium is not well-established.
  • Limited data exists on rapacuronium's onset and offset profiles at sub-paralyzing doses.

Purpose of the Study:

  • To rigorously investigate the dose-response relationship of rapacuronium.
  • To characterize the onset and offset profiles of rapacuronium.

Main Methods:

  • Studied 47 adult patients (ASA I-II) undergoing tracheal intubation without muscle relaxants.
  • Anesthesia maintained with nitrous oxide, propofol, and alfentanil.
  • Measured first dorsal interosseous muscle electromyogram, determined ED50 and ED95 using regression analysis, and estimated onset times.

Related Experiment Videos

Main Results:

  • Calculated ED50 and ED95 values for rapacuronium were 0.39 ± 0.08 and 0.75 ± 0.16 mg/kg, respectively.
  • Peak effect (90%) after a single ED95 dose was achieved in 77 ± 17 seconds.
  • Clinical duration of action was 6.1 ± 1.1 minutes.

Conclusions:

  • The ED95 of rapacuronium is significantly lower than prior estimates.
  • Rapucuronium's onset profile is comparable to succinylcholine.
  • Spontaneous recovery from rapacuronium is faster than mivacurium but slower than succinylcholine.