Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epstein-Barr virus and multiple sclerosis.

A Ascherio1, M Munch

  • 1Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.

Epidemiology (Cambridge, Mass.)
|October 6, 2000
PubMed
Summary

Epstein-Barr virus (EBV) infection is strongly linked to multiple sclerosis (MS) risk. This systematic review found EBV-positive individuals have a significantly higher odds of developing MS, supporting EBV

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomechanical aspects of the posteromedial split in bicondylar tibial plateau fractures-a finite-element investigation.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2020
Same author

Practical implementation of automated closed-loop insulin delivery: A French position statement.

Diabetes & metabolism·2020
Same author

Rapid suppression of bone formation marker in response to sleep restriction and circadian disruption in men.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Impact of long-term daylight deprivation on retinal light sensitivity, circadian rhythms and sleep during the Antarctic winter.

Scientific reports·2018
Same author

First Accurate Normalization of the β-delayed α Decay of ^{16}N and Implications for the ^{12}C(α,γ)^{16}O Astrophysical Reaction Rate.

Physical review letters·2018
Same author

Research Letter: Folic acid supplementation and intake of folate in pregnancy in relation to offspring risk of autism spectrum disorder.

Psychological medicine·2017

Area of Science:

  • Virology
  • Neurology
  • Epidemiology

Background:

  • The Epstein-Barr virus (EBV) has been hypothesized to contribute to the development of multiple sclerosis (MS).
  • Previous epidemiological studies on the EBV-MS link have yielded inconclusive results due to high rates of prior EBV infection in healthy individuals.

Purpose of the Study:

  • To systematically review and synthesize evidence from case-control studies investigating the association between EBV serology and MS.

Main Methods:

  • A systematic review of published case-control studies was performed.
  • Eight studies comprising 1,005 MS cases and 1,060 controls were included.
  • EBV serology status in MS patients and control groups was compared.

Main Results:

Related Experiment Videos

  • A significant association was found between EBV seropositivity and MS.
  • The summary odds ratio for MS in EBV seropositive versus seronegative individuals was 13.5 (95% CI = 6.3-31.4).
  • The observed association demonstrated strength, consistency, and high serological sensitivity and specificity.

Conclusions:

  • The findings strongly suggest a role for EBV in the etiology of multiple sclerosis.
  • The results are unlikely to be explained by non-specific immune activation in MS patients.