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Updated: Aug 5, 2026

Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants
Published on: December 1, 2010
CT-guided needle procedures for brain lesions: 20 years' experience
1Division of Neurosurgery, Nyack Hospital, NY, USA.
Objective:
To assess free-hand needle procedures with CT guidance for biopsy and drainage of brain lesions.
Method:
A series of 184 operations was carried out on 120 patients over a 20-year period. Sixty (60) cases of suspected neoplasm were biopsied; 40 cases of intracerebral hemorrhage and 20 cases of intracranial suppuration underwent drainage.
Results:
The morbidity and mortality of the methods described were quite low due to steroid therapy, prophylactic antibiotics, and careful preparation of the access site. There was one complication of postoperative hemorrhage in a patient with metastatic melanoma.
Conclusions:
The simple and accurate techniques presented continue to have widespread application in the practice of neurosurgery and compare quite favorably with techniques using more elaborate equipment, stereotactic frames, and intraoperative monitoring.

