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Effects of low-density lipoproteins on blood coagulation and fibrinolytic activity
O A Azizova1, E V Roitman, I I Dement'eva
1Laboratory of Biophysical Basis of Pathology, Institute of Physicochemical Medicine, Russian Ministry of Health.
Bulletin of Experimental Biology and Medicine
|October 7, 2000
Abstract:
In vitro experiments showed that copper-oxidized low-density lipoproteins activate factors of the prothrombin complex in the whole blood and inhibit fibrin generation in both blood and plasma. Moreover, oxidized low-density lipoproteins inhibit fibrinolysis and impair the structure of fibrin clot, which results in hypercoagulation.