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[Evaluation of major pharmacokinetic parameters of high molecular weight polyethylene oxide using polymer
G A Chernysheva1, M B Plotnikov, V I Smol'iakova
1Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, Russia.
Abstract:
The pharmacokinetics of high-molecular-weight polyethylene oxide (HMW PEO)--a parent compound in the polietoks drug--was experimentally studied in cats. A PEO concentration in the blood was determined by measuring a decrease in the hydrodynamic resistance for a blood sample flowing in the turbulent mode via a glass capillary. Variation of the polymer concentration in the blood is described by a single-exponent function with an elimination halftime of T1/2 = 3.15 h. According to the calculation, 99.6% of the initial amount of PEO losses the antiturbulent activity within 24 h.