Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Homocysteine elevation in sickle cell disease.

E A Lowenthal1, M S Mayo, P E Cornwell

  • 1Division of Nephrology, University of Alabama at Birmingham, 35233-6959, USA.

Journal of the American College of Nutrition
|October 7, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remote delivery of a weight management intervention for adults with intellectual disabilities: Results from a randomized non-inferiority trial.

Disability and health journal·2024
Same author

Tuberculosis in a Boar.

The Journal of comparative medicine and veterinary archives·2022
Same author

Transcervical endometrial biopsy in the baboon: Effects on the menstrual cycle and relations to protein and dry matter content and histology.

American journal of primatology·2020
Same author

Weight management for adolescents with intellectual and developmental disabilities: Rationale and design for an 18month randomized trial.

Contemporary clinical trials·2016
Same author

A virtual reality intervention (Second Life) to improve weight maintenance: Rationale and design for an 18-month randomized trial.

Contemporary clinical trials·2015
Same author

Weight management for individuals with intellectual and developmental disabilities: rationale and design for an 18 month randomized trial.

Contemporary clinical trials·2013
Same journal

Response to Commentary.

Journal of the American College of Nutrition·2021
Same journal

Risk of Osteoarthritis is Positively Associated with Vitamin D Status, but Not Bone Mineral Density, in Older Adults in the United States.

Journal of the American College of Nutrition·2021
Same journal

Nutrient Intake and Muscle Measures in Geriatric Outpatients.

Journal of the American College of Nutrition·2021
Same journal

Analyzing Blood Pressure Ascent during Aging in Non-Diabetics: Focusing on Links to Insulin Resistance and Body Fat Mass.

Journal of the American College of Nutrition·2021
Same journal

Effect of a Free-Living Ketogenic Diet on Feasibility, Satiety, Body Composition, and Metabolic Health in Women: The Grading Level of Optimal Carbohydrate for Women (GLOW) Study.

Journal of the American College of Nutrition·2021
Same journal

The Prophylactic Activity of <i>Punica granatum</i> L. mesocarp Protects Preadipocytes against Ribosylated BSA-Induced Toxicity.

Journal of the American College of Nutrition·2021
See all related articles

Patients with sickle cell disease have higher homocysteine levels, a risk factor for vascular issues. This occurs despite higher folate intake, suggesting increased folic acid needs in this population.

Area of Science:

  • Hematology
  • Nutritional Biochemistry
  • Vascular Medicine

Background:

  • Sickle cell disease (SCD) is associated with frequent ischemic complications.
  • Hyperhomocysteinemia is a known risk factor for atherosclerosis and venous thrombosis.
  • Elevated homocysteine may contribute to SCD-related ischemic events.

Purpose of the Study:

  • To investigate plasma homocysteine concentrations in adults with sickle cell disease.
  • To determine if SCD patients have higher homocysteine levels compared to healthy controls.
  • To explore the relationship between homocysteine, folate, and vitamin B12 in SCD.

Main Methods:

  • Plasma homocysteine, vitamin B12, and folate levels were measured.
  • Study included 49 adults with SCD and 16 healthy Black controls.

Related Experiment Videos

  • All SCD patients received daily folic acid supplementation (1 mg).

    • Main Results:

    • SCD patients exhibited approximately 1.5-fold higher median plasma homocysteine levels (p=0.0008).
    • Elevated homocysteine persisted even after excluding patients with renal insufficiency.
    • Plasma folate levels were also 1.5-fold higher in SCD patients (p=0.0498).
    • No significant differences in vitamin B12 or homocysteine levels between transfused and non-transfused SCD patients were observed.

    Conclusions:

    • Patients with sickle cell disease have elevated plasma homocysteine despite higher folate levels.
    • This suggests a potentially higher nutritional requirement for folic acid in SCD.
    • Increased folate intake may be necessary to normalize homocysteine levels in this population.