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Epilepsy surgery in infancy.

R P Saneto¹, E Wyllie

¹Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA.

Seminars in Pediatric Neurology

|October 7, 2000

Summary

This summary is machine-generated.

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Pediatric epilepsy surgery is increasingly performed in infants for severe cases. Seizure freedom is achieved in about 60% of infants, similar to older patients, with potential developmental benefits.

Area of Science:

Pediatric Neurosurgery
Epileptology
Developmental Neuroscience

Background:

Intractable epilepsy is increasingly managed surgically in infants.
Common causes include cortical malformations and low-grade tumors.
Other etiologies include Sturge-Weber syndrome and hemimegalencephaly.

Purpose of the Study:

To review the efficacy and considerations of epilepsy surgery in infants.
To highlight the diagnostic modalities and outcomes in this population.

Main Methods:

Review of diagnostic tools: video electroencephalography (EEG), magnetic resonance imaging (MRI), and positron emission tomography (PET).
Analysis of surgical outcomes from small series.
Consideration of risks, benefits, and developmental impact.

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Main Results:

Approximately 60% of infants achieve seizure freedom post-surgery, comparable to older age groups.
Surgical risks are significant and should be weighed against epilepsy severity.
Potential for developmental improvement exists, though data is limited.

Conclusions:

Infantile epilepsy surgery offers comparable seizure control rates to older patients.
Careful presurgical evaluation is crucial to balance risks and benefits.
Further research with long-term follow-up is needed to confirm developmental outcomes.