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Micturitional disturbance in neuro-Behçet's syndrome
R Sakakibara1, T Hattori, K Boku
1Department of Neurology, Chiba University School of Medicine, Japan. sakaki@med.m.chiba-u.ac.jp
Autonomic Neuroscience : Basic & Clinical
|October 7, 2000
Summary
Micturitional disturbances are common in neuro-Behçet's syndrome (NBS). Urodynamic studies reveal supranuclear pelvic nerve dysfunction as the likely cause of these urinary symptoms.
Area of Science:
- Neurology
- Urology
Background:
- Micturitional disturbance is a known complication of neuro-Behçet's syndrome (NBS).
- The pathophysiology and urodynamic findings associated with these disturbances remain poorly understood.
Purpose of the Study:
- To investigate micturitional histories and urodynamic findings in patients diagnosed with neuro-Behçet's syndrome.
Main Methods:
- Nine patients with NBS underwent micturitional history assessment.
- Neurological and imaging (CT/MRI) findings were analyzed to determine lesion locations.
- Symptomatic patients completed urodynamic studies, including post-micturition residual measurement, urethral pressure profilometry, and EMG cystometry.
Main Results:
- 67% of patients reported urinary symptoms such as frequency, urgency, urge incontinence, and voiding difficulty.
- Urodynamic studies indicated post-micturition residuals in 50% of patients, detrusor hyperreflexia in 5/6, and detrusor-sphincter dyssynergia in 2/6.
- Abnormalities in urethral pressure and bladder capacity were also observed.
Conclusions:
- Micturitional disturbances are frequent in patients with neuro-Behçet's syndrome.
- Supranuclear pelvic nerve dysfunction is implicated as the primary cause of these urinary issues.