Related Experiment Video
Updated: Aug 19, 2026

Double Whole Mount in situ Hybridization of Early Chick Embryos
Published on: October 27, 2008
Left-right asymmetry in BMP4 signalling pathway during chick gastrulation
1IECM, CNRS et Collège de France, FRE 2160, 49 bis avenue de la Belle Gabrielle, 94736, Nogent-sur-Marne, France. monsoro@infobiogen.fr
Abstract:
Determination of the left-right (L-R) axis was shown recently to implicate several genes, among which TGFbeta-related molecules such as Activin betaB, lefty1 and 2 and Nodal. We show here that Bmp4 and its signal transduction pathway partners BMPR IA and Smad1 are transiently expressed on the right side of Hensen's node, when L-R polarity is being established. Moreover, Smad1 is expressed asymmetrically in the nascent notochord. These observations suggest a role for a BMP4-dependent autocrine or paracrine mechanism during early L-R determination.
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