Related Experiment Video
Updated: Aug 9, 2026

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
Published on: December 16, 2016
Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development
D W Eib1, T M Holling, A Zwijsen
1Department of Animal Physiology, University of Nijmegen, Toernooiveld 1, 6525 ED, The, Nijmegen, Netherlands.
Abstract:
A novel transmembrane protein (designated X7365) containing two follistatin modules and an epidermal growth factor (EGF) domain has been described in the hypothalamic-pituitary axis of Xenopus laevis. We have now cloned the highly conserved mouse orthologue (M7365), and its mRNA was detected in many mesodermal and (neuro)ectodermal tissues in 8.5-day-old mouse embryos. During further development, M7365 mRNA expression became restricted to certain regions in the brain and to ganglia. In the adult mouse, the brain is the major site of M7365 expression.

