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Differences in degree of trapping between AR-R15896 and other uncompetitive NMDA receptor antagonists
T H Lanthorn1, G A Mealing, P Morley
1AstraZeneca R&D Boston, Rochester, New York 14602, USA.
Amino Acids
|October 12, 2000
Abstract:
NMDA antagonists like AR-R15896 have been selected on the basis of their good therapeutic indices. As Dr. Rogawski has pointed out, there may be a number of molecular factors which can improve the therapeutic index of NMDA antagonists. In this paper we will consider three factors; use-dependence, low affinity/fast kinetics, and partial trapping.