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Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
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Roughex mediates G(1) arrest through a physical association with cyclin A

S N Avedisov1, I Krasnoselskaya, M Mortin

  • 1Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.

Molecular and Cellular Biology
|October 12, 2000
PubMed
Summary

Roughex protein physically interacts with cyclin A, influencing its nuclear localization and degradation. This interaction inhibits cyclin A-dependent kinase activity, defining Roughex as a specialized cell cycle inhibitor.

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