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Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides
A Nefzi1, M A Giulianotti, N A Ong
1Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA.
Organic Letters
|October 13, 2000
Abstract:
The exhaustive reduction of resin-bound tripeptides with borane afforded three secondary amines and one primary amine. The treatment of the solid-support polyamines with thiocarbonyldiimidazole afforded, following cleavage of the solid support, the corresponding bis-cyclic thiourea in good purity and yield.