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Updated: Jul 21, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
Published on: September 6, 2012
Solid phase synthesis of mixture-based acyclic and heterocyclic small molecule combinatorial libraries from
A Nefzi1, J M Ostresh, R A Houghten
1Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, Building 2, Room 138, San Diego, CA 92121, USA.
Abstract:
The development of soluble mixture-based heterocyclic combinatorial libraries derived from amino acids and peptides is described. Starting with a "toolbox" of various chemical transformations, including alkylations, reductions, acylations, and the use of a variety of bifunctional reagents, the "libraries from libraries" concept has been expanded to encompass the development of more than fifty positional scanning combinatorial libraries each composed of tens of thousands of low molecular weight acyclic and heterocyclic compounds.
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