Related Experiment Video
Updated: Jul 16, 2026

The Aortic Ring Co-culture Assay: A Convenient Tool to Assess the Angiogenic Potential of Mesenchymal Stromal Cells In Vitro
Published on: September 18, 2017
Role of cyclooxygenases in angiogenesis
K M Leahy1, A T Koki, J L Masferrer
1Discovery Pharmacology, G. D. Searle/Monsanto (T3G), 800 North Lindbergh Boulevard, St. Louis, Missouri 63167, USA.
Abstract:
Angiogenesis is the process by which new blood vessels are formed. This process supports normal physiology as well as contributes to progression of disease. Progressive rheumatoid arthritis and growth of tumors are two pathologies to which angiogenesis contributes. In arthritis, we know that prostaglandins (PGs) and the enzyme cyclooxygenase-2, which catalyses prostaglandin production, are inflammatory mediators. These mediators are involved in rheumatoid arthritis and cancer-induced angiogenic processes. We discuss, herein, recent findings on the expression of cyclooxygenases in both rheumatoid arthritis and human cancer, and the links between COX-2, PGs, and angiogenesis. We also propose a model for the possible mechanistic interaction of the various cell types involved in angiogenesis.
Related Concept Videos
Mechanism of Angiogenesis
Regulation of Angiogenesis and Blood Supply
Nitric Oxide Signaling Pathway
Role of Matrix Metalloproteases in Degradation of ECM
A...
Overview of Cell-Matrix Interactions
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...

