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Structural and cellular changes during bone growth in healthy children.

A M Parfitt1, R Travers, F Rauch

  • 1Division of Endocrinology and Center for Osteoporosis and Metabolic Bone Disease, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Bone
|October 18, 2000
PubMed
Summary

This study provides the first histological analysis of human bone growth, revealing key changes in bone width, volume, and remodeling rates during childhood and adolescence. Findings detail bone formation and resorption processes essential for understanding skeletal development and adult bone health.

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Area of Science:

  • Orthopedics
  • Histology
  • Human Physiology

Background:

  • Normal postnatal bone growth is critical for lifelong skeletal health.
  • Histological studies of human bone growth have been lacking.
  • Understanding bone development informs pediatric and adult skeletal health.

Purpose of the Study:

  • To conduct the first histological analysis of normal postnatal bone growth in humans.
  • To characterize histomorphometric changes in the iliac bone from childhood to young adulthood.
  • To compare growth patterns with adult bone remodeling data.

Main Methods:

  • Histomorphometric analysis of iliac bone biopsies from 58 healthy individuals aged 1.5-23 years.
  • Utilized double tetracycline labeling in 48 subjects for mineralization studies.

Related Experiment Videos

  • Compared data with 109 healthy women aged 20-76 years for reference ranges and age-related regressions.

    • Main Results:

    • Significant age-related increases in core, cortical, and cancellous bone width.
    • Increased bone volume and trabecular thickness in cancellous bone.
    • Declining mineral apposition rates with age, but increased osteoblast lifespan due to increased wall thickness.

    Conclusions:

    • The ilium grows in width through periosteal apposition and endocortical resorption.
    • Cortical width increases significantly from childhood to young adulthood.
    • Bone remodeling rates must be high during growth to achieve necessary trabecular hypertrophy.