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Updated: Feb 23, 2026

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
Published on: November 10, 2023
[Dantrolene-induced pleurisy: a case report]
F Dohen1, V Montagne, E Lelieur
1Service de Pneumologie, Centre Hospitalier de Dunkerque 130, avenue Louis Herbeaux, B.P. 6.367, 59385 Dunkerque Cedex.
Abstract:
We report the case of a patient who developed dantrolene-induced pleurisy. Dantrolene (Dantrium) is a muscle relaxing agent used for the treatment of spastic neurological manifestations which has known liver toxicity. Lung toxicity is rarely reported. Six cases of dantrolene-induced pleurisy occurring after chronic administration (> 60 days) have been described in the literature. The pleurisy is associated with pleural and peripheral eosinophilia. Spontaneous regression a few days after withdrawal and radiological cure a few months later is the rule. The precise mechanism of this drug-induced pleural reaction remains unknown.
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