Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonprotruding colorectal neoplasms: epidemiologic viewpoint.

C A Rubio1

  • 1Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden. carlos.rubio@onkpat.ki.se

World Journal of Surgery
|October 19, 2000
PubMed
Summary

Colorectal neoplasias in Japan show more advanced histologic features, including high-grade dysplasia and early carcinomas, compared to Sweden. The underlying reasons for these differences in nonpolypoid adenoma progression remain unclear.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lymphocytic oesophagitis, eosinophilic oesophagitis and compound lymphocytic-eosinophilic oesophagitis I: histological and immunohistochemical findings.

Journal of clinical pathology·2016
Same author

Traditional serrated adenomas of the upper digestive tract.

Journal of clinical pathology·2015
Same author

European consensus on the histopathology of inflammatory bowel disease.

Journal of Crohn's & colitis·2013
Same author

The frequency of advanced adenoma in consulting patients: a nationwide survey in Iceland (2003-2006).

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2012
Same author

Usefulness of colonoscopic examination with indigo carmine in diagnosing microscopic colitis.

Endoscopy·2011
Same author

Further studies on the frequency and length of the glandulo-metaplastic esophageal mucosa in baboons.

In vivo (Athens, Greece)·2009

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Nonpolypoid colorectal neoplasias present diverse histologic phenotypes.
  • Previous studies suggest geographic variations in colorectal cancer incidence and characteristics.

Purpose of the Study:

  • To compare the histologic features of nonprotruding colorectal neoplasias between Sweden and Japan.
  • To investigate potential differences in the advancement and aggressiveness of these lesions.

Main Methods:

  • Histologic review of 781 nonprotruding colorectal neoplasias (adenomas and early carcinomas) from Sweden and Japan.
  • Standardized criteria were applied by a single observer.

Main Results:

  • Swedish neoplasias predominantly showed low-grade dysplasia (LGD) (82.8%), while Japanese lesions more frequently exhibited high-grade dysplasia (HGD) (42.4%).

Related Experiment Videos

  • A higher proportion of Japanese lesions were intramucosal or submucosal carcinomas (IMCs/SMCs) (15.0%) compared to Swedish lesions (3.0%).
  • Japanese nonpolypoid colorectal neoplasias were histologically more advanced and aggressive than those in Sweden.

    • Conclusions:

    • Significant histologic differences exist in nonpolypoid colorectal neoplasias between Swedish and Japanese populations.
    • The etiology of these observed differences in lesion advancement and aggressiveness is currently unknown.
    • Nonprotruding adenomas may originate from lymphoid-associated colorectal mucosa.