Stimulation by haptenic Salmonella polysaccharides of murine and rabbit lymphocytes

The Freeman polysaccharide - the hapten of lipopolysaccharide - induced a blast transformation of mouse and rabbit spleen lymphocytes. The magnitude of the response in rabbit was quite similar to that obtained by lipopolysaccharide whereas in mice it was weaker. The stimulation of lymphocytes of both species did not require the presence of macrophages. Similar results were obtained with four LPS and their correspondent haptens prepared from S. typhi-murium, S. abortus-equi, S. johannesburg R+ and R-.