Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variance component methods for detecting complex trait loci.

J Blangero1, J T Williams, L Almasy

  • 1Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA.

Advances in Genetics
|October 19, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pathways and Roadblocks: Navigating Family-Building for Sexual and Gender Minority People Assigned Male at Birth.

Perspectives on sexual and reproductive health·2026
Same author

Differential gene expression study in whole blood identifies candidate genes for psychosis in African American individuals.

Schizophrenia research·2025
Same author

Engaging Sexual and Gender Minority (SGM) Communities for Health Research: Building and Sustaining PRIDEnet.

Journal of community engagement and scholarship·2024
Same author

Publisher Correction: Brain charts for the human lifespan.

Nature·2022
Same author

Brain charts for the human lifespan.

Nature·2022
Same author

Genetic differentiation between baboon subspecies: Relevance for biomedical research.

American journal of primatology·2020
Same journal

Shaping mammalian genomes: The regulation and co-option of transposable elements in early development and gametogenesis.

Advances in genetics·2026
Same journal

Transposable elements in aging: From biomarkers to effectors.

Advances in genetics·2026
Same journal

Transposable elements in human cancer: Regulation, activation, and genomic consequences.

Advances in genetics·2026
Same journal

Retrotransposons as both "architects" and "saboteurs" in the nervous system.

Advances in genetics·2026
Same journal

Transposable element analysis in OMICS data.

Advances in genetics·2026
Same journal

The implication of lncRNAs in the regulation of inflammation.

Advances in genetics·2026
See all related articles

Variance component linkage analysis is a powerful statistical tool for identifying genes controlling complex traits. This method effectively analyzes large pedigrees and complex genetic models, including gene-gene and gene-environment interactions.

Area of Science:

  • Statistical genetics
  • Quantitative trait loci (QTL) analysis

Background:

  • Variance component (VC) analysis is a key statistical method for complex trait genetics.
  • It enables the study of quantitative trait loci (QTL) influencing complex phenotypes.

Purpose of the Study:

  • To review the statistical features of VC linkage analysis.
  • To highlight its power and robustness in genetic studies.

Main Methods:

  • Utilizes variance component models for linkage analysis.
  • Accommodates large pedigrees and multiple loci simultaneously.
  • Examines genotype-environment interaction and epistasis.

Main Results:

  • VC analysis is a robust statistical tool.

Related Experiment Videos

  • Demonstrates power in localizing and evaluating QTL.
  • Effectively handles complex genetic models and interactions.

    • Conclusions:

    • VC linkage analysis is a versatile and powerful approach for complex trait genetics.
    • Its robustness makes it suitable for diverse genetic datasets and models.