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Updated: Aug 19, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
[Atrio-biventricular electrostimulation in the treatment of congestive heart failure. Case report]
M L Bencić1, D Milicić, D Kosi
1Klinicki bolnicki centar, Zagreb.
Insights
Multisite, biventricular cardiac pacing shows promise for improving heart failure symptoms and quality of life in patients with dilated cardiomyopathy. This advanced pacing technique offers functional benefits, aligning with current research trends.
Area of Science:
- Cardiology
- Medical Devices
Background:
- Indications for permanent cardiac pacing have expanded, including dilated cardiomyopathy and hypertrophic obstructive cardiomyopathy.
- Dual-chamber pacing has shown benefits in heart failure with dilated cardiomyopathy.
- Multisite, biventricular pacing has emerged as a potentially more effective approach.
Observation:
- A patient with dilated cardiomyopathy (NYHA class IV), awaiting heart transplantation, received a multisite pacemaker (InSync).
- The patient met established criteria for multisite pacemaker implantation.
Findings:
- The patient experienced functional improvement during an eleven-month follow-up.
- Observed enhancements included a better 6-minute walking test performance.
- Quality of life also improved significantly.
Implications:
- Multisite, biventricular pacing may offer significant benefits for select heart failure patients.
- This approach aligns with and supports current literature on advanced cardiac pacing.
- Further research into multisite pacing for advanced heart failure is warranted.
Abstract:
Over the past few years, indications for permanent cardiac pacing have been broadened. Accordingly, American Heart Association and American College of Cardiology included dilated cardiomyopathy, hypertrophic obstructive cardiomyopathy and pacing for prevention of atrial fibrillation into indications for permanent cardiac pacing. Studies have described favourable effect of dual chamber cardiac pacing in congestive heart failure in dilated cardiomyopathy, regardless of etiology. In the past two years, even more beneficial effect was associated with multisite, biventricular cardiac pacing. On the basis of the reported results, a multisite pacemaker InSync was implanted to a patient with dilated cardiomyopathy (NYHA class IV), who was also on the list for heart transplantation, and who fulfilled other criteria for implantation of multisite pacemaker. During the eleven-month follow-up, functional improvement, better 6-minute walking test and enhanced quality of life of the patient were observed, which is in accordance with the literature data.
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