Related Experiment Video
Updated: May 24, 2025
Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
Published on: November 10, 2023
[Post-infectious bronchiolitis obliterans in children: A rare and potentially devastating disease]
J Mazenq1, J-C Dubus1, P Chanez2
1Service de pneumologie pédiatrique, CHU Timone enfants, Assistante publique des Hôpitaux de Marseille, 264, rue Saint Pierre, 13005 Marseille, France; Inserm, INRAE, C2VN Marseille, Aix-Marseille université, Marseille, France.
Insights
Post-infectious bronchiolitis obliterans (PIBO) is a severe pediatric lung disease often caused by adenovirus. Research focuses on understanding its mechanisms, identifying biomarkers, and improving treatment for this condition.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Pathology
Background:
- Post-infectious bronchiolitis obliterans (PIBO) is a rare, severe pediatric pulmonary disease.
- Adenovirus infection is a common cause, with risk factors including male sex, hypoxemia, and mechanical ventilation.
Purpose of the Study:
- To summarize the current understanding of PIBO, including its causes, diagnosis, and mechanisms.
- To highlight the need for further research into biomarkers and improved management strategies.
Main Methods:
- Review of clinical history, bronchial obstruction, and radiological findings for diagnosis.
- Pathological examination focusing on airway epithelial lesions and bronchiolar fibrosis.
Main Results:
- PIBO involves chronic inflammation, tissue remodeling, and fibrosis in the bronchioles.
- Airway epithelial lesions, potentially viral-induced, are key mechanisms.
Conclusions:
- Current understanding of PIBO is based on clinical and pathological features.
- Further research is crucial for developing specific treatments and improving patient outcomes.
Abstract:
Post-infectious bronchiolitis obliterans (PIBO) is a rare but severe pulmonary disease in children, often associated with adenovirus infection. Risk factors include male sex, hypoxemia, and mechanical ventilation. Diagnosis is based on clinical history, bronchial obstruction, and radiological abnormalities. PIBO is characterized by chronic inflammation leading to tissue remodeling and bronchiolar fibrosis. Airway epithelial lesions, potentially linked to viral infection, are considered key mechanisms of PIBO. In the absence of specific treatments, research efforts aim to better understand mechanisms of PIBO, identify biomarkers, and improve management strategies.
Related Concept Videos
01:17Pulmonary Cycle: Exhalation
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:22Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
01:23The Bronchial Tree
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD: