Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The square stent-based large vessel occluder: an experimental pilot study.

D Pavcnik1, B T Uchida, H Timmermans

  • 1Dotter Interventional Institute, Oregon Health Sciences University, Portland 97201, USA. pavcnikd@ohsu.edu

Journal of Vascular and Interventional Radiology : JVIR
|October 21, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term follow-up results of the multicenter phase II trial of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of standard tyrosine kinase inhibitor therapy.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

The Signature Program: Bringing the Protocol to the Patient.

Clinical pharmacology and therapeutics·2015
Same author

Reverse endoventricular artificial obturator in tricuspid valve position. Experimental feasibility research study.

Physiological research·2014
Same author

Instructional technology and educational reform: 1977.

The Behavior analyst·2012
Same author

A lost art.

The Behavior analyst·2012
Same author

Memories of psychology in the twenties.

The Behavior analyst·2012

This study shows a new stent-based device effectively occludes large vessels in animal models. The device, made from stainless steel and porcine submucosa (SIS), proved reliable for both immediate and long-term closure.

Area of Science:

  • Biomedical Engineering
  • Vascular Surgery
  • Materials Science

Background:

  • Vascular occlusion devices are crucial for managing various cardiovascular conditions.
  • Existing devices may have limitations in large vessel applications.
  • Development of novel, reliable occlusion systems is an ongoing area of research.

Purpose of the Study:

  • To evaluate a novel square stent-based vascular occlusion device for large vessels.
  • To assess the in vitro and in vivo performance of this device.
  • To determine the efficacy and safety of the device for acute and chronic occlusion.

Main Methods:

  • Square stent-based large vessel occluders (LVO) were constructed using stainless steel and porcine small intestine submucosa (SIS).
  • Devices were tested in vitro using a flow model and in vivo in pigs and dogs, placed in major arteries.

Related Experiment Videos

  • Angiography, gross, and histologic evaluations were performed post-implantation with follow-up up to 3 months.

    • Main Results:

    • The LVOs demonstrated ease of delivery and adaptation to vessel lumens, with precise placement capabilities.
    • In vitro tests showed competency under high pressure, and in vivo, complete occlusion was achieved rapidly and maintained.
    • Histologic analysis revealed successful tissue integration, remodeling, and endothelialization of the SIS material within 2 months.

    Conclusions:

    • The SIS LVO is an effective and reliable device for acute and chronic occlusion in large vessels.
    • The device shows promise for clinical applications requiring permanent vascular closure.
    • Successful tissue integration and remodeling support the long-term viability of the device.