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Related Experiment Videos

Blastocyst-ET and monozygotic twinning.

B Behr1, J D Fisch, C Racowsky

  • 1Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305, USA.

Journal of Assisted Reproduction and Genetics
|October 24, 2000
PubMed
Summary

Blastocyst transfer in in vitro fertilization (IVF) using cell-free culture systems is associated with an increased rate of monozygotic twinning. This finding is significant for patient counseling during fertility treatments.

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Area of Science:

  • Reproductive medicine
  • Embryology
  • Genetics

Background:

  • Assisted reproductive technologies, including in vitro fertilization (IVF), have evolved significantly.
  • Blastocyst transfer has become a common practice in IVF.
  • Previous studies suggested a link between IVF and monozygotic twinning, particularly with assisted hatching.

Purpose of the Study:

  • To investigate the incidence of monozygotic twinning following blastocyst transfer.
  • To evaluate the association between commercially available, cell-free culture systems and monozygotic twinning rates.
  • To assess outcomes with unmanipulated blastocysts.

Main Methods:

  • Retrospective analysis of 199 pregnancies resulting from IVF blastocyst embryo transfer (ET) across multiple US fertility centers.

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  • Embryos were cultured in commercial cell-free media and transferred at the blastocyst stage.
  • The primary endpoint was the rate of monozygotic twinning.

    • Main Results:

    • A total of 199 pregnancies were analyzed.
    • Monozgotic twinning occurred in 10 out of 199 (5%) of these pregnancies.
    • All identified cases of monozygotic twinning were monochorionic diamnionic.

    Conclusions:

    • Blastocyst transfer using modern cell-free culture systems is associated with a notable increase in monozygotic twinning.
    • This phenomenon appears to be real and warrants consideration.
    • The findings have implications for patient counseling regarding IVF treatment outcomes.