Related Experiment Videos
CD72, a negative regulator of B-cell responsiveness.
1Department of Medicine, Stanford University School of Medicine, California, USA. jrparnes@leland.stanford.edu
Immunological Reviews
|October 24, 2000
Summary
CD72 regulates B-cell development and responsiveness. CD72-deficient mice revealed its crucial role as a nonredundant negative regulator in B-cell activation and development.
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Background:
- Lymphocyte responsiveness is modulated by regulatory proteins.
- CD72, a C-type lectin superfamily member, is expressed on B lymphocytes.
- Previous studies suggested both positive and negative regulatory roles for CD72.
Purpose of the Study:
- To investigate the physiological role of CD72 in B-lymphocyte development and activation.
- To clarify the regulatory function of CD72 in the immune system.
Main Methods:
- Generation of CD72-deficient mice.
- Analysis of B-cell development and activation in these mice.
- Utilizing anti-CD72 antibodies in prior studies.
Main Results:
- CD72 is essential for normal B-cell development.
- CD72 functions as a negative regulator of B-cell responsiveness.
- SHP-1 recruitment by CD72 suggests an inhibitory mechanism.
Conclusions:
- CD72 is a nonredundant regulator of B-cell development.
- CD72 negatively regulates B-cell activation thresholds.
- Elucidating CD72's role provides insights into immune regulation.