Related Experiment Videos
Changes in lipid profiles in non diabetic, non nephrotic patients commencing continuous ambulatory peritoneal
E O'Riordan1, D J O'Donoghue, P A Kalra
1Department of Renal Medicine, Hope Hospital, Salford, U.K.
Insights
Continuous ambulatory peritoneal dialysis (CAPD) significantly increases harmful LDL cholesterol levels in patients. This pro-atherogenic lipid change warrants consideration when choosing dialysis methods due to cardiovascular risks.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Clinical Chemistry
Background:
- Patients with end-stage renal disease often have altered lipid profiles.
- Cardiovascular disease is a leading cause of mortality in dialysis patients.
- The impact of initiating continuous ambulatory peritoneal dialysis (CAPD) on lipid profiles requires further elucidation.
Purpose of the Study:
- To investigate the effects of commencing CAPD on the lipid profiles of non-diabetic, non-nephrotic patients.
- To compare lipid changes over a 9-month period before and after CAPD initiation.
Main Methods:
- A longitudinal study was conducted on eighteen non-diabetic, non-nephrotic patients.
- Lipid profiles, serum albumin, and body weight were monitored for 9 months pre- and post-CAPD commencement.
- Statistical analysis was performed to assess significant changes in lipid parameters.
Main Results:
- Mean total cholesterol levels increased significantly (4.98 to 5.42 mmol/L) post-CAPD initiation.
- Low-density lipoprotein (LDL) cholesterol showed a sustained rise up to 9 months after starting CAPD.
- High-density lipoprotein (HDL) cholesterol remained stable, while serum albumin and body weight decreased.
Conclusions:
- Commencing CAPD leads to a pro-atherogenic shift in lipid profiles, primarily driven by increased LDL cholesterol.
- This lipid alteration is not observed with hemodialysis and may increase cardiovascular risk.
- The findings suggest that CAPD's impact on lipids should be a factor in selecting dialysis modality for at-risk patients.
Abstract:
This study examined the effect on patient lipid profile of commencing continuous ambulatory peritoneal dialysis (CAPD). We followed eighteen non diabetic, non nephrotic patients for 9 months before and after dialysis commencement and compared lipid profiles. Mean cholesterol levels rose from 4.98 mmol/L to 5.42 mmol/L (p < 0.05). This change was chiefly due to a rise in low density lipoprotein (LDL) cholesterol. The LDL cholesterol rose after dialysis commencement and continued to rise up to 9 months later. High-density lipoprotein (HDL) cholesterol remained stable. Serum albumin and body weight fell during follow-up, suggesting that the rise in cholesterol was not a reflection of enhanced nutritional status. This study highlights the pro-atherogenic change in lipids that results from commencing CAPD. This phenomenon is not seen in hemodialysis, and it should be considered when selecting a dialysis modality, given the increased risk of cardiovascular disease in the dialysis population.