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Oleanane acid from Myrica cerifera.

M Nagai1, N Sakurai, N Yumoto

  • 1Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. nagumo@hoshi.ac.jp

Chemical & Pharmaceutical Bulletin
|October 25, 2000
PubMed
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Researchers isolated a novel oleanane triterpenoid, myrica acid, from Myrica cerifera twigs. Its structure was elucidated as 3beta-hydroxy-1-oxoolean-11,13(18)-dien-28-oic acid using chemical and spectral data.

Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Organic Chemistry

Background:

  • Myrica cerifera L. (Myricaceae) is a plant source of various bioactive compounds.
  • Triterpenoids are a significant class of natural products with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize novel compounds from the twigs of Myrica cerifera.
  • To determine the chemical structure of a newly discovered triterpenic acid.

Main Methods:

  • Phytochemical investigation of Myrica cerifera twig extract.
  • Isolation of constituents using chromatographic techniques.
  • Structure elucidation through comprehensive chemical and spectroscopic analyses (e.g., NMR, MS).

Main Results:

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  • A new oleanane triterpenic acid, designated myrica acid, was successfully isolated.
  • Myrica acid was identified as 3beta-hydroxy-1-oxoolean-11,13(18)-dien-28-oic acid.
  • Several known constituents, including myricalactone, were also identified.

Conclusions:

  • The study reports the discovery and structural determination of myrica acid, a novel triterpenoid.
  • This finding expands the knowledge of the phytochemical profile of Myrica cerifera.
  • The isolated compounds may serve as leads for further pharmacological investigations.