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Updated: Jun 30, 2026

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
Focused Beam Reflectance Measurement as a Complementary Tool for Monitoring Disintegration and Drug Release Processes
Tatsuki Tadauchi1, Eriko Yamazoe1, Takaaki Ito1
1Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
None:
Focused beam reflectance measurement (FBRM) has been used for investigating tablet dissolution behavior. However, few studies have used FBRM to analyze sustained-release formulations. In this study, we prepared tablets containing hydroxypropyl methylcellulose (HPMC), a widely used sustained-release excipient, and evaluated dissolution behavior using both conventional dissolution testing and FBRM. To assess the effect of drug solubility on FBRM parameters, we also compared acetaminophen (readily soluble in water) with ethenzamide (poorly soluble in water). Conventional dissolution testing revealed a difference of approximately 360 min among the different HPMC grades in the time required to reach 60% drug release, while FBRM detected an approximate threefold difference in the final particle counts. These findings suggest that FBRM is a useful analytical tool for elucidating the dissolution behavior of sustained-release formulations.
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