Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

BRCA1: exploring the links to transcription.

A N Monteiro1

  • 1Dept of Cell Biology, Weill Medical College of Cornell University, New York, NY 10021, USA.

Trends in Biochemical Sciences
|October 26, 2000
PubMed
Summary

The breast and ovarian cancer gene, BRCA1, is key in DNA repair and gene activity. Disrupting BRCA1

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In situ protein expression of RRM1, ERCC1, and BRCA1 in metastatic breast cancer patients treated with gemcitabine-based chemotherapy.

Cancer investigation·2009
Same author

Three-color intranuclear staining for measuring mitosis and apoptosis in cells transfected with a GFP-tagged histone.

Biotechnic & histochemistry : official publication of the Biological Stain Commission·2009
Same author

Cancer risks in first degree relatives of BRCA1 mutation carriers: effects of mutation and proband disease status.

Journal of medical genetics·2005
Same author

Yeast-based assays for detection and characterization of mutations in BRCA1.

Breast disease·2005
Same author

BRCA1 can stimulate gene transcription by a unique mechanism.

EMBO reports·2001
Same author

Functional analysis of BRCA1 C-terminal missense mutations identified in breast and ovarian cancer families.

Human molecular genetics·2001

Area of Science:

  • Genetics
  • Molecular Biology
  • Cancer Research

Background:

  • The BRCA1 gene is linked to hereditary breast and ovarian cancers.
  • Understanding BRCA1's function is critical for cancer prevention and treatment.

Purpose of the Study:

  • To elucidate the specific roles of the BRCA1 gene.
  • To investigate the connection between BRCA1's function and tumor development.

Main Methods:

  • Review of recent scientific literature on BRCA1.
  • Analysis of experimental data on BRCA1's cellular processes.

Main Results:

  • BRCA1 participates in DNA repair mechanisms.
  • BRCA1 plays a role in regulating gene transcription.
  • BRCA1 is a multifunctional protein.

Conclusions:

  • BRCA1's involvement in DNA repair and transcriptional regulation is confirmed.
  • Altered transcriptional activity of BRCA1 may drive tumor formation.

Related Experiment Videos