Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug-excipient interactions and their affect on absorption.

Jackson1, Young, Pant

  • 17250 Parkway Drive, Suite 430, 21076, Hanover MD, USA

Pharmaceutical Science & Technology Today
|October 26, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What determines the outcome after total mesorectal excision for rectal carcinoma-15 years experience of a specialist surgical unit.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2013
Same author

Control of edema in kidney disease.

Case reports. Children's Memorial Hospital (Chicago, Ill.)·2010
Same author

Drugs for Alzheimer's disease

BMJ (Clinical research ed.)·2000
Same author

Who Shall Lead Us?

MedGenMed : Medscape general medicine·2000
Same author

The Good Medical Teacher.

MedGenMed : Medscape general medicine·2000
Same author

The good physician

MedGenMed : Medscape general medicine·2000

Drug excipient interactions significantly impact drug availability. Understanding these physicochemical and physiological processes is crucial for effective drug formulation and regulatory compliance.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Formulation Development

Background:

  • Excipients are often considered inert components in drug formulations.
  • However, excipients can profoundly influence the pharmacological availability of active pharmaceutical ingredients.
  • The extent of this influence varies based on drug properties and excipient characteristics.

Purpose of the Study:

  • To identify physicochemical and physiological processes affected by drug-excipient interactions.
  • To explore the underlying mechanisms of these interactions.
  • To discuss the regulatory implications of drug-excipient interactions.

Main Methods:

  • Literature review of drug-excipient interactions.
  • Analysis of physicochemical processes (e.g., solubility, dissolution).

Related Experiment Videos

  • Exploration of physiological processes (e.g., absorption, metabolism).

    • Main Results:

    • Drug-excipient interactions can alter drug solubility, dissolution rates, and absorption.
    • Mechanisms include complex formation, adsorption, and changes in microenvironment pH.
    • These interactions have significant implications for drug efficacy and safety.

    Conclusions:

    • Excipients are not inert and play a critical role in drug performance.
    • Understanding drug-excipient interactions is essential for rational drug formulation.
    • Regulatory agencies emphasize the importance of characterizing these interactions for product approval.