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[Lipid profile in newborns with intrauterine growth retardation]
1Departamento de Obstetricia y Puericultura, Facultad de Medicina, Universidad de Concepción, Chile. marmolin@udec.cl
Insights
Newborns with intrauterine growth retardation exhibit elevated triglyceride levels compared to healthy newborns. This finding suggests potential early programming of coronary disease risk factors.
Area of Science:
- Neonatal Medicine
- Cardiovascular Health
- Metabolic Disorders
Context:
- Intrauterine growth retardation (IUGR) in newborns may predispose to adult coronary heart disease.
- Early life programming of disease risk is a critical area of research.
- Understanding metabolic profiles in IUGR infants is essential for long-term health assessment.
Purpose:
- To quantify and compare serum lipid profiles in newborns diagnosed with intrauterine growth retardation (IUGR) versus normal term infants.
- Specifically measure total cholesterol, HDL, LDL cholesterol, triglycerides, and apoproteins A1 and B.
- Investigate potential differences in lipid parameters between symmetrical and asymmetrical IUGR.
Summary:
- A study of 135 newborns with IUGR and 116 controls found no significant differences in total cholesterol, HDL, LDL cholesterol, or apoproteins.
- However, newborns with IUGR showed significantly higher triglyceride levels (45 +/- 27 mg/dl) compared to controls (36 +/- 19 mg/dl).
- Elevated triglycerides were noted in both genders with asymmetrical IUGR and in infants with mild or severe IUGR, but not moderate IUGR.
Impact:
- Newborns with IUGR present with higher triglyceride levels, indicating a distinct metabolic profile.
- This finding highlights a potential early biomarker for increased cardiovascular risk in individuals born with IUGR.
- Further research can explore the long-term implications of these elevated triglycerides on adult cardiovascular health.
Background:
The X syndrome, related to coronary disease in adults, could be possibly programmed priory to delivery, in children with intrauterine growth retardation.
Aim:
To measure serum lipids in newborns with symmetrical or asymmetrical intrauterine growth retardation.
Patients And Methods:
One hundred thirty-five newborns with intrauterine growth retardation and 116 normal term newborns, with 38 to 41 gestational weeks, were studied. Total, HDL, and LDL cholesterol, triglycerides and apoproteins. A1 and B were measured in umbilical cord blood samples.
Results:
No differences in total, HDL, LDL cholesterol, apoproteins A1 and B were observed between the study groups. Triglycerides were higher in newborns with intrauterine growth retardation, compared to normal term newborns (45 +/- 27 and 36 +/- 19 mg/dl respectively, p < 0.001). Differences in serum triglyceride levels respect to controls were observed in both male and female newborns with asymmetrical growth retardation. Likewise the differences respect to controls were observed in newborns with mild or severe but not with moderate growth retardation.
Conclusions:
Newborns with intrauterine growth retardation have higher triglyceride levels than normal term newborns.