Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Published on: February 23, 2014

Recurrent laryngeal nerve transposition in guinea pigs.

J T Heaton¹, J B Kobler, E A Goldstein

¹Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA.

The Annals of Otology, Rhinology, and Laryngology

|October 29, 2000

Summary

Researchers recovered motor signals from the recurrent laryngeal nerve (RLN) by transposing it into the sternohyoid muscle (SH) in guinea pigs. This may enable better control of prosthetic voice devices for laryngectomees.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

From protection to amplification: Imperfect chytridiomycosis prophylaxis increases infections in wild amphibians.

bioRxiv : the preprint server for biology·2026

Same author

Asymmetric cross-strain protection for amphibians exposed to a fungal-metabolite prophylactic treatment.

Biology letters·2021

Same author

Vocal fold submucosal infusion technique in phonomicrosurgery.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2012

Same author

EFFECTS OF AIR IN THE VASCULAR SYSTEM AND THE MECHANISM OF DEATH.

British medical journal·2010

Same author

VASO-DILATOR EFFECTS OF THE PNEUMOGASTRIC NERVE.

British medical journal·2010

Same author

ON THE NERVOUS CONTROL OF ABDOMINAL BLOOD VESSELS AND VISCERA.

British medical journal·2010

Area of Science:

Biomedical Engineering
Neuroscience
Regenerative Medicine

Background:

Laryngectomy patients often lose vocalization ability.
Prosthetic voice aids require intuitive control signals.
Residual laryngeal motor nerve signals offer potential for improved control.

Purpose of the Study:

To investigate the feasibility of using recurrent laryngeal nerve (RLN) signals for controlling prosthetic voice devices.
To assess the reinnervation and functional recovery of a transposed RLN in guinea pigs.

Main Methods:

Recurrent laryngeal nerve (RLN) transposition into the ipsilateral denervated sternohyoid muscle (SH) in 8 guinea pigs.
Electromyographic (EMG) recordings to monitor reinnervation in awake animals.
Nerve stimulation, section experiments, and histochemical analysis to confirm RLN source and muscle fiber type transformation.

More Related Videos

Cochlear Implantation in the Guinea Pig

Cochlear Implantation in the Guinea Pig

Published on: June 15, 2018

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

Published on: January 13, 2023

Related Experiment Videos

Last Updated: Jul 16, 2026

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Published on: February 23, 2014

Cochlear Implantation in the Guinea Pig

Cochlear Implantation in the Guinea Pig

Published on: June 15, 2018

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

Published on: January 13, 2023

Main Results:

Successful reinnervation of the sternohyoid muscle (SH) by the recurrent laryngeal nerve (RLN) within 4–14 weeks.
Demonstrated laryngeal-like motor activity in the reinnervated SH during respiration, sniffing, swallowing, and vocalization.
Histochemical analysis revealed a shift towards fatigue-resistant muscle fibers in the reinnervated SH, similar to laryngeal muscles.

Conclusions:

Recurrent laryngeal nerve (RLN) transposition can salvage laryngeal control signals.
This method may provide a viable pathway for controlling advanced prosthetic voice devices.
Potential for restoring vocal function in laryngectomees through nerve reconstruction.