[Anti-inflammatory and analgesic action of S-adenosyl-L-methionine (SAMe) in experimental tests on laboratory...

S-adenosyl-L-methionine (SAMe) always plays an important role in the metabolism of catecholamines. Since the importance of the latter in the inflammatory process has been reported by several Authors, we examined the effect of SAMe in various tests of acute inflammation (carrageenin and white egg oedema) and chronic inflammation (cotton pellet induced granuloma, adjuvant induced arthritis). Considering the positive results we have obtained and being aware that many drugs with antiinflammatory activity also have an antalgic activity, we examined the effects of a treatment with SAMe on animals subjected to analgesic tests: hot plate and streching by acetic acid in mice.