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Menopause01:28

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Clonidine in menopausal flushing: a double-blind trial.

P Bolli, F O Simpson

    The New Zealand Medical Journal
    |September 24, 1975
    PubMed
    Summary

    Low-dose clonidine effectively treated menopausal flushing in hypertensive women. This antihypertensive medication demonstrated superior efficacy compared to placebo in a double-blind trial.

    Area of Science:

    • Pharmacology
    • Obstetrics and Gynecology
    • Cardiovascular Medicine

    Background:

    • Menopausal flushing is a common vasomotor symptom experienced by many women.
    • Hypertension is a prevalent comorbidity that requires careful consideration when selecting treatments.

    Purpose of the Study:

    • To evaluate the efficacy of low-dose clonidine in managing menopausal flushing.
    • To assess the effectiveness of clonidine compared to placebo in hypertensive women.

    Main Methods:

    • A double-blind clinical trial was conducted.
    • Twelve hypertensive women experiencing menopausal flushing were enrolled.
    • Participants received either clonidine (150mug daily) or a placebo.

    Main Results:

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    • A significant placebo effect was observed.
    • Clonidine at a daily dose of 150mug showed greater effectiveness in reducing menopausal flushing than placebo.
    • The antihypertensive drug clonidine proved beneficial for this indication.

    Conclusions:

    • Low-dose clonidine is an effective treatment option for menopausal flushing in hypertensive women.
    • The benefits of clonidine in managing vasomotor symptoms outweigh the placebo effect.
    • Further research may explore optimal dosing and long-term effects.