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Related Experiment Videos

Tear meniscus changes during cotton thread and Schirmer testing.

N Yokoi1, S Kinoshita, A J Bron

  • 1Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan. nyokoi@ophth.kpu-m.ac.jp

Investigative Ophthalmology & Visual Science
|October 29, 2000
PubMed
Summary
This summary is machine-generated.

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The Schirmer test (S-T) more significantly impacts tear meniscus curvature than the cotton thread test (CT-T), particularly in dry eye patients. This suggests S-T wetting is influenced by tear meniscus hydrostatic pressure.

Area of Science:

  • Ophthalmology
  • Tear Film Dynamics
  • Dry Eye Disease Research

Background:

  • Accurate assessment of tear reservoir function is crucial for diagnosing and managing dry eye disease.
  • The cotton thread test (CT-T) and Schirmer test (S-T) are common methods to evaluate tear production, but their precise impact on tear dynamics is not fully understood.
  • Understanding how these tests affect the tear meniscus curvature can provide insights into tear film stability and ocular surface health.

Purpose of the Study:

  • To investigate the differential effects of the cotton thread test (CT-T) and Schirmer test (S-T) on the tear reservoir.
  • To evaluate these effects by measuring changes in the radius of tear meniscus curvature using a novel video meniscometer.

Main Methods:

  • Measured tear meniscus curvature radii (R) using a video meniscometer in normal volunteers and patients with severe dry eye and punctal occlusion.

Related Experiment Videos

  • Performed a 1-minute CT-T followed by a 1-minute S-T after a 10-minute interval.
  • Recorded tear meniscus curvature at baseline (R(0)), 30 seconds (R(30)), and 60 seconds (R(60)) during each test.

    • Main Results:

    • In dry eye patients, the S-T significantly diminished tear meniscus radius (R) more than the CT-T (P = 0.01).
    • Tear meniscus alteration in dry eye patients occurred within 30 seconds of the S-T.
    • Significant correlations were found between baseline R and S-T results, and between changes in R and S-T results in both normal and dry eye groups, but not with CT-T results.

    Conclusions:

    • The Schirmer test's wetting effect appears influenced by negative hydrostatic pressure within the tear meniscus.
    • The study provides insights into the tear dynamics during the Schirmer test.
    • No definitive conclusion could be drawn regarding the relationship between meniscus radius and cotton thread wetting in this study.