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Cholic acid is accumulated spontaneously, driven by membrane deltapH, in many lactobacilli
P Kurdi1, H W van Veen, H Tanaka
1Laboratory of Applied Microbiology, Research Group of Molecular Bioscience, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
Journal of Bacteriology
|October 29, 2000
Abstract:
Many lactobacilli from various origins were found to apparently lack cholic acid extrusion activity. Cholic acid was accumulated spontaneously, driven by the transmembrane proton gradient. Accumulation is a newly identified kind of interaction between intestinal microbes and unconjugated bile acids and is different from extrusion and modification, which have been described previously.