Related Experiment Video
Updated: Aug 6, 2026

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
Published on: June 11, 2017
Alpha(1)-adrenoceptors (alpha(1)-AR) and vascular smooth muscle cell growth
1Department of Medicine, Stanford University School of Medicine, and Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA. bhoffman@stanford.edu
Background:
Smooth muscle cells in vascular tissue, like tissue within the urogenital sinus, undergo growth and proliferation.
Methods:
This review attempts to compare and contrast the mechanisms and controlling factors involved in prostatic and vascular tissue. There is a particular focus on the role of catecholamines and alpha-adrenoceptors (alpha-ARs), and on the effects of alpha(1)-AR antagonists (blockers) on cellular dynamics. RESULTS AND CONCLUSIONS The situation in vascular tissue appears analagous to that in prostatic tissue. Certain AR-antagonists, in addition to altering smooth muscle contraction, may have other actions on cellular dynamics.
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