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Prostaglandin E2 on the electroencephalogram.

J J Amy, M Dierick, M Thiery

    Prostaglandins
    |September 1, 1975
    PubMed
    Summary
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    Prostaglandin E2 (PGE2) does not appear to cause seizures or abnormal electroencephalogram (E.E.G.) patterns in patients undergoing pregnancy termination. This study investigated E.E.G. changes before and after PGE2 administration in 54 subjects.

    Area of Science:

    • Obstetrics and Gynecology
    • Neuroscience
    • Pharmacology

    Background:

    • Reports suggested potential convulsions and abnormal electroencephalogram (E.E.G.) patterns with intra-amniotic prostaglandin F2alpha (PGF2alpha) use.
    • This prompted an investigation into the neurological effects of prostaglandin administration.

    Purpose of the Study:

    • To evaluate the epileptogenic potential of prostaglandin E2 (PGE2) when used for pregnancy termination.
    • To assess the impact of PGE2 on electroencephalogram (E.E.G.) patterns in diverse patient groups.

    Main Methods:

    • Electroencephalogram (E.E.G.) recordings were performed before and after PGE2 administration in 54 subjects.
    • Subjects included pregnant and non-pregnant individuals, with 23 known epileptics.
    • One seizure occurred in a patient with a history of psychomotor attacks who had not taken anticonvulsants.

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    Main Results:

    • PGE2 did not alter E.E.G. tracings in subjects with normal baseline E.E.G.s.
    • In subjects with abnormal E.E.G.s, one showed deterioration and three showed improvement.
    • No E.E.G. abnormalities or seizures were directly attributed to PGE2 in compliant patients.

    Conclusions:

    • Prostaglandin E2 (PGE2) is not epileptogenic at the doses required for pregnancy termination.
    • The study provides evidence against PGE2 inducing seizures or significant E.E.G. abnormalities in this context.