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[Development of ossification in children with chronic digestive insufficiency (author's transl)]
Insights
Chronic digestive insufficiency in children can cause delayed bone ossification. Early, consistent dietary intervention is key for improvement, though other health issues and treatments can hinder progress.
Area of Science:
- Pediatric Endocrinology
- Developmental Biology
- Radiology
Context:
- Chronic digestive insufficiency affects numerous children globally.
- Bone ossification is a critical indicator of growth and development in pediatrics.
- Fluoroscopic imaging is a standard tool for assessing skeletal maturation.
Purpose:
- To investigate the relationship between chronic digestive insufficiency and bone ossification in children.
- To evaluate the impact of dietary interventions on ossification patterns.
- To identify factors influencing ossification outcomes in affected children.
Summary:
- This study observed 84 children with chronic digestive insufficiency over several years using fluoroscopic controls.
- A significant portion (48/71) exhibited retarded ossification, while others had normal or advanced development.
- Dietary interventions led to catch-up growth in some, but constant retardation or progression of delay occurred in others due to late diagnosis, dietary non-compliance, comorbidities, or corticosteroid use.
- Normal or advanced ossification was observed in 30 children with early, consistent dietary management and few additional health issues.
- Ossification development correlated with body height but not weight gain.
Impact:
- Highlights the critical role of early and consistent dietary management in mitigating growth disturbances in pediatric digestive insufficiency.
- Underscores the need for timely diagnosis and comprehensive treatment strategies, considering potential confounding factors.
- Provides insights into the long-term skeletal development implications of chronic digestive issues in children, informing clinical practice and future research.
Abstract:
In 84 children suffering from chronic insufficiency of digestion, ossification of both hands was observed by means of fluoroscopic controls for several years. In 48 of 71 patients there was a retarded ossification; in 23 it was normal, or respectively more advanced. 18 boys and girls succeeded in making up for there retardation by means of consequent diet so that it might be regarded as a "spurt of growth". But in 10 of them retardation was constant, and in 14 children it increased. The causes of insufficient improvement were: late diagnosis and therapy, failures of diet, but also additional diseases--different from digestive insufficiency--, and long-term use of corticosteroides. In 30 of 84 children ossification was always normal or advanced. They had received early and consequent diet for years. Only in few cases, slight or moderate diseases were diagnosed. Development of ossification was parallel to body height, but not to weight gain.