Cross-sectional study of osteopenia with quantitative MR imaging and bone densitometry
F W Wehrli1, J A Hopkins, S N Hwang
1Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce St, 1 Founders, Philadelphia, PA 19104, USA. wehrli@oasis.rad.upenn.edu
Radiology
|November 4, 2000
Summary
Bone marrow R2
Area of Science:
- Medical Imaging
- Bone Biology
- Osteoporosis Research
Background:
- Bone mineral density (BMD) is a key indicator of bone health.
- Vertebral fractures are a significant complication of osteoporosis.
- Current methods for fracture prediction have limitations.
Purpose of the Study:
- To evaluate cancellous bone-induced intravoxel spin dephasing rate (R2') and its relationship with BMD and marrow fat.
- To assess R2', BMD, and marrow composition as predictors of vertebral fracture status.
Main Methods:
- R2', R2, and marrow fat fraction were measured in lumbar vertebrae and proximal femur of 139 subjects.
- BMD was assessed using dual-energy x-ray absorptiometry (DXA).
- Statistical analyses examined R2', BMD, and marrow fat as determinants of vertebral fracture.
Main Results:
- The Ward triangle (BMD) and trochanter (R2') were the strongest individual predictors of fracture status.
- Combining R2' and BMD significantly improved fracture prediction compared to BMD alone.
- Multivariate regression including marrow fat fraction further enhanced fracture prediction accuracy.
- R2' correlated with BMD, with variations influenced by trabecular orientation.
- R2 was negatively correlated with marrow fat fraction, consistent with findings in osteoporosis.
Conclusions:
- Cancellous bone marrow R2' measurement, particularly in the proximal femur, offers valuable information.
- Integrating R2' with BMD enhances the prediction of vertebral fracture status.
- Marrow fat fraction also contributes to improved fracture risk assessment.
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