Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skeletal drug delivery systems.

A K Jain1, R Panchagnula

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar-160 062, Punjab, India.

International Journal of Pharmaceutics
|November 4, 2000
PubMed
Summary

Selective drug delivery to bone remains challenging. Skeletal Drug Delivery Systems (SDDS) use bone fillers in self-setting cement for targeted drug delivery, improving therapeutic effectiveness in bone diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Profiling CARD14 gene expression in Indian Psoriasis patients.

Scientific reports·2024
Same author

Exploring the diversity of virulence genes in the <i>Magnaporthe</i> population infecting millets and rice in India.

Frontiers in plant science·2023
Same author

The Implementation of a Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) Program at a Level 1 New England Trauma Center: Feasibility and Early Outcomes.

The American surgeon·2023
Same author

Added value of the measles-rubella supplementary immunization activity in reaching unvaccinated and under-vaccinated children, a cross-sectional study in five Indian districts, 2018-20.

Vaccine·2022
Same author

Deep learning model for predicting tunnel damages and track serviceability under seismic environment.

Modeling earth systems and environment·2022
Same author

Role of GeneXpertMTB/RIF in the diagnosis of cutaneous tuberculosis.

The Indian journal of tuberculosis·2022

Area of Science:

  • Biomedical Engineering
  • Pharmaceutical Sciences
  • Orthopedics

Background:

  • Selective drug delivery is crucial for treating diseases where drugs can adversely affect healthy tissues.
  • Poor perfusion in skeletal tissue complicates effective drug delivery, posing a significant challenge for pharmaceutical scientists.
  • The development of specialized systems is needed to ensure adequate drug concentrations at the target site over therapeutic timeframes.

Purpose of the Study:

  • To review the applicability of various materials used as bone fillers in skeletal drug delivery systems.
  • To highlight advancements in overcoming the challenges of targeted drug delivery to bone tissue.
  • To underscore the importance of the Skeletal Drug Delivery System (SDDS) in enhancing therapeutic outcomes for bone diseases.

Main Methods:

  • Review of existing literature on skeletal drug delivery systems and bone filler materials.
  • Analysis of the principles behind the first Skeletal Drug Delivery System (SDDS) introduced in 1970.
  • Examination of how self-setting cement functions as both a bone filler and a drug delivery vehicle.

Main Results:

  • Skeletal Drug Delivery Systems (SDDS) enable high drug concentrations directly at skeletal tissue sites.
  • Self-setting cement acts as a bone filler and facilitates localized drug release, improving treatment efficacy.
  • Various materials have been investigated for their suitability as bone fillers in SDDS.

Conclusions:

  • Skeletal drug delivery systems offer a promising approach to enhance the treatment of bone diseases.
  • The use of bone fillers within self-setting cement is key to achieving targeted and effective drug delivery to bone.
  • Continued research into bone filler materials is essential for optimizing skeletal drug delivery systems.

Related Experiment Videos