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Can pooling be used for seroprevalence studies of hepatitis C?
G M Stephens1, J M Raboud, L Karakas
1Diagnostic Virology and Reference Laboratory, University of British Columbia, Vancouver, British Columbia, Canada.
Journal of Clinical Microbiology
|November 4, 2000
Abstract:
Two hepatitis C antibody assays were used to test diluted positive sera. Dilutions of 1 in 5, 1 in 10, and 1 in 20 all resulted in loss of reactivity, with the greatest losses occurring in samples with low and moderate reactivities. These results disqualify pooling as a strategy for seroprevalence studies and screening programs.