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Updated: Aug 4, 2026

Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain
Published on: April 20, 2019
Exploring the pain "neuromatrix"
1University of Pittsburgh Medical Center, PET Facility, B-938 PUH, 200 Lothrop Street, Pittsburgh, PA 15213, USA. stuart@pet.upmc.edu
Abstract:
A considerable number of functional imaging studies have demonstrated the involvement of multiple central regions during the experience of pain. These regions process information in circuits that can broadly be assumed to process the affective, sensory, cognitive, motor, inhibitory, and autonomic responses stimulated by a noxious event. The concept of a "neuromatrix" for pain processing is, therefore, well supported. There is, however, scant evidence for any particular regional or circuit dysfunction during clinical pain. To be clinically useful, functional imaging may have to step beyond the generalities of the neuromatrix.
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