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"Tissue" transglutaminase in animal development.

M Piacentini1, C Rodolfo, M G Farrace

  • 1Department of Biology, University of Rome Tor Vergata, Italy. mauro.piacentini@uniroma2.it

The International Journal of Developmental Biology
|November 4, 2000
PubMed
Summary
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Tissue transglutaminase (tTG) plays a key role in programmed cell death (PCD) by cross-linking proteins. Its expression is linked to cell death during animal reproduction and development, preventing inflammation.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Developmental Biology

Background:

  • Tissue transglutaminase (tTG) is a multifunctional enzyme involved in protein post-translational modification.
  • tTG catalyzes Ca2+-dependent reactions, forming protein cross-links and incorporating biogenic amines.
  • tTG gene expression is specifically associated with apoptosis or programmed cell death (PCD) in vertebrates.

Purpose of the Study:

  • To review the current knowledge on tTG expression and regulation in animal reproduction and development.
  • To explore the relationship between tTG expression and the induction of PCD in these contexts.

Main Methods:

  • Review of existing scientific literature on tTG function, expression, and regulation.
  • Analysis of data linking tTG to PCD in animal reproduction and development.

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Main Results:

  • Ca2+-dependent activation of tTG in PCD leads to detergent-insoluble protein polymers.
  • This protein scaffold may stabilize dying cells, preventing the release of harmful intracellular components.
  • Data consistently strengthen the association between tTG expression and PCD induction.

Conclusions:

  • tTG plays a crucial role in the cellular mechanisms of PCD.
  • Understanding tTG's role in reproduction and development is vital for comprehending PCD.
  • tTG activity may prevent inflammatory responses and tissue damage during cell death.