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"Allergic sinusitis" revisited.

R G Slavin1, J R Leipzig, H M Goodgold

  • 1Department of Internal Medicine, Saint Louis University School of Medicine, Missouri, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|November 4, 2000
PubMed
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This study investigated allergic sinusitis, finding no evidence of sinus inflammation in adults with severe allergic rhinitis. Advanced imaging techniques confirmed the absence of sinus involvement in these allergic rhinitis patients.

Area of Science:

  • Otolaryngology
  • Immunology
  • Radiology

Background:

  • The term "allergic sinusitis" is commonly used but its validity is debated.
  • Investigating the existence of allergic inflammation within the sinuses is crucial for accurate diagnosis and treatment.

Purpose of the Study:

  • To determine if allergic inflammation is present in the sinuses of individuals with severe allergic rhinitis.
  • To assess five highly symptomatic adults sensitive to ragweed for sinus inflammation.

Main Methods:

  • Utilized three advanced imaging techniques: SPECT bone imaging, SPECT Indium-111 labeled white blood cell (WBC) uptake, and Fluorodeoxyglucose F-18 Positron Emission Tomography (PET) scanning.
  • Applied these imaging modalities to evaluate the sinus cavities for signs of inflammation.

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Main Results:

  • No evidence of sinus involvement was detected in association with severe allergic rhinitis.
  • Imaging results did not support the presence of inflammation in the sinuses of the study participants.

Conclusions:

  • Despite using three distinct imaging modalities, inflammation of the sinuses could not be demonstrated in patients diagnosed with allergic rhinitis.
  • The findings question the existence of "allergic sinusitis" as a distinct inflammatory condition of the sinuses.